HORDB
A database of peptide hormones
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Protein Information
ID:
hd00021
Active Ingredients:
Abarelix
DRUGBANK Accession Number:
DB00106 (BTD00051, BIOD00051)
Active Sequence:
XXXSYNLXPA
Sequence Length:
10
Type:
Small Molecule
Description:
Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Disease:
Prostate cancer
CAS:
183552-38-7
SMILES:
CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)N(C)C(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C
Drug Information
Drug Name
Strength
Dosage Form/Route
Company
Marketing Status
Approval year
PLENAXIS
100 MG/VIAL
INJECTABLE; INTRAMUSCULAR
SPECIALITY EUROPEAN
Discontinued
2003