HORDB

ID: hor006756
Uniprot ID: Q4U4N3
Protein name: Alpha-latrotoxin-associated protein 2
Gene name: NA
Organism: Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
Family: Arthropod CHH/MIH/GIH/VIH hormone family
Source: Animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Latrodectus (genus), Theridiidae (family), Araneoidea (superfamily), Orbiculariae , Entelegynae , Araneomorphae (suborder), Araneae (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: MLKLICIAFLVTVLTLVAGQDSLDPAEFGCADDVNQAELLKNNDICLQCEDLHKEGVVFSLCKTNCFTTEYFQHCVKDLEEAKKEPPE
Length: 88(1-88)
Propeptide: MLKLICIAFLVTVLTLVAGQDSLDPAEFGCADDVNQAELLKNNDICLQCEDLHKEGVVFSLCKTNCFTTEYFQHCVKDLEEAKKEPPE
Signal peptide: MLKLICIAFLVTVLTLVAG
Modification: T20 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana.
Mechanism: Co-purifies with latroinsectotoxin.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q4U4N3-F1.pdb

hor006756_AF2.pdb

hor006756_ESM.pdb

Mass:	1139039	Formula:	C433H685N107O137S8
Absent amino acids:	RW	Common amino acids:	L
pI:	4.15	Basic residues:	9
Polar residues:	22	Hydrophobic residues:	33
Hydrophobicity:	2.95	Boman Index:	-9704
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	96.36
Instability Index:	2971.36	Extinction Coefficient cystines:	1865
Absorbance 280nm:	21.44