HORDB

ID: hor006724
Uniprot ID: P25329
Protein name: Glycoprotein hormones alpha chain
Gene name: CGA
Organism: Physeter macrocephalus (Sperm whale) (Physeter catodon)
Family: Glycoprotein hormones subunit alpha family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Physeter (genus), Physeteridae (family), Odontoceti (parvorder), Cetacea (infraorder), Whippomorpha (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity; GO:0016913 follicle-stimulating hormone activity
GO BP: GO:0007186 G protein-coupled receptor signaling pathway; GO:0010469 regulation of signaling receptor activity; GO:0010893 positive regulation of steroid biosynthetic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0016914 follicle-stimulating hormone complex

Sequence: FPNGZFTMQGCPZCKLKQNKYFSKLGAPIYZCMGCCFSRAYPTPARSKKTMLVPKNITSZATCCVAKAFTKATVMGNARVQNHTZCHCSTCYYHKS
Length: 96
Propeptide: FPNGZFTMQGCPZCKLKQNKYFSKLGAPIYZCMGCCFSRAYPTPARSKKTMLVPKNITSZATCCVAKAFTKATVMGNARVQNHTZCHCSTCYYHKS
Signal peptide: NA
Modification: NA
Glycosylation: T56 N-linked (GlcNAc...) asparagine;T82 N-linked (GlcNAc...) asparagine
Mutagenesis: NA

Function: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006724_AF2.pdb

hor006724_ESM.pdb

Mass:	1167850	Formula:	C439H680N124O115S14
Absent amino acids:	DEW	Common amino acids:	CKT
pI:	9.79	Basic residues:	16
Polar residues:	40	Hydrophobic residues:	22
Hydrophobicity:	-21.98	Boman Index:	-11125
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	40.73
Instability Index:	3975	Extinction Coefficient cystines:	8075
Absorbance 280nm:	85