HORDB

ID: hor006665
Uniprot ID: Q2XXR7
Protein name: AVIToxin-VAR2
Gene name: NA
Organism: Varanus varius (Lace monitor lizard) (Lacerta varia)
Family: AVIT (prokineticin) family
Source: animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Varanus (genus), Varanidae (family), Varanoidea (superfamily), Paleoanguimorpha , Anguimorpha (infraorder), Toxicofera , Episquamata , Unidentata , Bifurcata , Squamata (order), Lepidosauria (class), Sauria , Sauropsida , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Sequence: AVITGACDKDLQCGEGMCCAVSLWIRSIRICTPLGSSGEDCHPLSHKVPFDGQRKHHTCPCLPNLVCGQTSPGKHKCLPEFKNVF
Length: 85
Propeptide: MRSLLCAPLLLLLLSAGESAVITGACDKDLQCGEGMCCAVSLWIRSIRICTPLGSSGEDCHPLSHKVPFDGQRKHHTCPCLPNLVCGQTSPGKHKCLPEFKNVF
Signal peptide: MRSLLCAPLLLLLLSAGES
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2. Potently contracts gastrointestinal (GI) smooth muscle.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006665_AF2.pdb

hor006665_ESM.pdb

Mass:	1070725	Formula:	C396H630N116O115S11
Absent amino acids:	Y	Common amino acids:	C
pI:	7.9	Basic residues:	14
Polar residues:	30	Hydrophobic residues:	23
Hydrophobicity:	-13.53	Boman Index:	-10356
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	71.06
Instability Index:	5987.29	Extinction Coefficient cystines:	6125
Absorbance 280nm:	72.92