HORDB

ID: hor006656
Uniprot ID: Q21508
Protein name: Probable insulin-like peptide alpha-type 2
Gene name: ins-22
Organism: Caenorhabditis elegans
Family: Insulin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: AHTDKYVRTLCGKTAIRNIANLCPPKPEMKGICSTGEYPSITEYCSMGFSDSQIKFMCCDNQ
Length: 62(22-83)
Propeptide: MHTTTILICFFIFLVQVSTMDAHTDKYVRTLCGKTAIRNIANLCPPKPEMKGICSTGEYPSITEYCSMGFSDSQIKFMCCDNQ
Signal peptide: MHTTTILICFFIFLVQVSTMD
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006656_AF2.pdb

hor006656_ESM.pdb

Mass:	798619	Formula:	C294H466N80O93S9
Absent amino acids:	W	Common amino acids:	CIKST
pI:	7.75	Basic residues:	8
Polar residues:	26	Hydrophobic residues:	13
Hydrophobicity:	-38.06	Boman Index:	-10175
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	53.55
Instability Index:	3100.48	Extinction Coefficient cystines:	4845
Absorbance 280nm:	79.43

PubMed ID: 9851916
Title: Genome sequence of the nematode C. elegans: a platform for investigating biology.
PubMed ID: 9548970
Title: New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.