HORDB

ID: hor006648
Uniprot ID: P70074
Protein name: Progonadoliberin-1
Gene name: gnrh1
Organism: Pagrus major (Red sea bream) (Chrysophrys major)
Family: GnRH family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Pagrus (genus), Sparidae (family), Spariformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSYGLSPGGKRDLDSLSDTLGDIIERFPHADSPCSVLGCAEEPPFPKMYRMKGFIGSGTDRDNGHRTYKK
Length: 72(24-95)
Propeptide: MAPQTSNLWLLLVVMMVMSQGCCQHWSYGLSPGGKRDLDSLSDTLGDIIERFPHADSPCSVLGCAEEPPFPKMYRMKGFIGSGTDRDNGHRTYKK
Signal peptide: MAPQTSNLWLLLVVMMVMSQGCC
Modification: T1 Pyrrolidone carboxylic acid;T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006648_AF2.pdb

hor006648_ESM.pdb

Mass:	929456	Formula:	C351H537N101O108S4
Absent amino acids:		Common amino acids:	G
pI:	7.51	Basic residues:	13
Polar residues:	25	Hydrophobic residues:	15
Hydrophobicity:	-85.83	Boman Index:	-16790
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	50.14
Instability Index:	5056.67	Extinction Coefficient cystines:	10095
Absorbance 280nm:	142.18