General Information

  • ID:  hor006646
  • Uniprot ID:  P69109
  • Protein name:  Progonadoliberin-3
  • Gene name:  gnrh3
  • Organism:  Oncorhynchus nerka (Sockeye salmon) (Salmo nerka)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  Brain.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QHWSYGWLPGGKRSVGELEATIKMMDTGGVVALPEETSAHVSERLRPYDVILKKWMPHK
  • Length:  59(24-82)
  • Propeptide:  MDLSNRTVVQVVVLALVAQVTLSQHWSYGWLPGGKRSVGELEATIKMMDTGGVVALPEETSAHVSERLRPYDVILKKWMPHK
  • Signal peptide:  MDLSNRTVVQVVVLALVAQVTLS
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P69109-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006646_AF2.pdbhor006646_ESM.pdb

Physical Information

Mass: 773946 Formula: C302H471N83O84S3
Absent amino acids: CFN Common amino acids: GEKLV
pI: 9.07 Basic residues: 11
Polar residues: 15 Hydrophobic residues: 18
Hydrophobicity: -50.68 Boman Index: -8536
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 75.93
Instability Index: 6936.61 Extinction Coefficient cystines: 19480
Absorbance 280nm: 335.86

Literature

  • PubMed ID:  8674859
  • Title:  Characterization of the Pacific salmon gonadotropin-releasing hormone gene, copy number and transcription start site.
  • PubMed ID:  8546809
  • Title:  Two differing precursor genes for the salmon-type gonadotropin-releasing hormone exist in salmonids.