HORDB

ID: hor006618
Uniprot ID: P0C0P5
Protein name: Neuropeptide S precursor
Gene name: NPS
Organism: Bos taurus (Bovine)
Family: NA
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032230 positive regulation of synaptic transmission, GABAergic; GO:0045760 positive regulation of action potential; GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO CC: GO:0005576 extracellular region

Sequence: HPISSSKVPGKSDYFVILLNSCPTRMDRRVGLDFLKPILEKTLMKRSFRNGVGTGMKKTSFRRAKS
Length: 66(24-89)
Propeptide: MIGSLKFNFILFLLISTMHMFWCHPISSSKVPGKSDYFVILLNSCPTRMDRRVGLDFLKPILEKTLMKRSFRNGVGTGMKKTSFRRAKS
Signal peptide: MIGSLKFNFILFLLISTMHMFWC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006618_AF2.pdb

hor006618_ESM.pdb

Mass:	864539	Formula:	C331H551N99O90S4
Absent amino acids:	QW	Common amino acids:	KSR
pI:	11.69	Basic residues:	16
Polar residues:	21	Hydrophobic residues:	18
Hydrophobicity:	-47.73	Boman Index:	-15017
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	72.27
Instability Index:	4783.94	Extinction Coefficient cystines:	1490
Absorbance 280nm:	22.92