General Information

  • ID:  hor006548
  • Uniprot ID:  P51922
  • Protein name:  Progonadoliberin-3
  • Gene name:  gnrh3
  • Organism:  Porichthys notatus (Plainfin midshipman)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Porichthys (genus), Porichthyinae (subfamily), Batrachoididae (family), Batrachoidiformes (order), Batrachoidaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  QHWSYGWLPGGKRSVGELEATIRMMGTGGVVSLPEETSAQTQERLRPYNIINDGGYFNRKKRFFHE
  • Length:  66(24-89)
  • Propeptide:  MRPYNVIVVMVVLLALVLHAVLSQHWSYGWLPGGKRSVGELEATIRMMGTGGVVSLPEETSAQTQERLRPYNIINDGGYFNRKKRFFHE
  • Signal peptide:  MRPYNVIVVMVVLLALVLHAVLS
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P51922-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006548_AF2.pdbhor006548_ESM.pdb

Physical Information

Mass: 874506 Formula: C337H515N99O98S2
Absent amino acids: C Common amino acids: G
pI: 9.7 Basic residues: 11
Polar residues: 23 Hydrophobic residues: 17
Hydrophobicity: -81.21 Boman Index: -14897
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 57.58
Instability Index: 5367.88 Extinction Coefficient cystines: 15470
Absorbance 280nm: 238

Literature

  • PubMed ID:  7657161
  • Title:  Structure, localization, and molecular phylogeny of a GnRH cDNA from a paracanthopterygian fish, the plainfin midshipman (Porichthys notatus).