General Information

  • ID:  hor006468
  • Uniprot ID:  Q867W1
  • Protein name:  C-terminal peptide
  • Gene name:  NA
  • Organism:  Procambarus clarkii (Red swamp crayfish)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Olfactory lobe and accessory lobe, olfactory globular tract, olfactory lobe cells (at protein level). Widely distributed throughout nervous system.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Procambarus (genus), Cambarinae (subfamily), Cambaridae (family), Astacoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AGGDSLYEPGKALASACQVAVEACAAWFPGPE
  • Length:  32(43-74)
  • Propeptide:  MCVQTRMLVAVAVVLVVLAVLSDPVSAGYRKPPFNGSIFGKRAGGDSLYEPGKALASACQVAVEACAAWFPGPEKK
  • Signal peptide:  MCVQTRMLVAVAVVLVVLAVLSDPVSA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  GYRKPPFNGSIF-amide may be involved in olfaction and contraction of hindgut.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q867W1-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006468_AF2.pdbhor006468_ESM.pdb

Physical Information

Mass: 371968 Formula: C140H209N35O45S2
Absent amino acids: HIMNRT Common amino acids: A
pI: 3.78 Basic residues: 1
Polar residues: 9 Hydrophobic residues: 14
Hydrophobicity: 20.63 Boman Index: -315
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 67.5
Instability Index: 5477.19 Extinction Coefficient cystines: 7115
Absorbance 280nm: 229.52

Literature

  • PubMed ID:  14723891
  • Title:  Identification of GYRKPPFNGSIFamide (crustacean-SIFamide) in the crayfish Procambarus clarkii by topological mass spectrometry analysis.