General Information

  • ID:  hor006457
  • Uniprot ID:  Q32L79
  • Protein name:  Insulin-like peptide INSL6 A chain
  • Gene name:  INSL6
  • Organism:  Bos taurus (Bovine)
  • Family:  Insulin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  GYSEKCCQKGCTKEELIIACLPYIDYENL
  • Length:  29(171-199)
  • Propeptide:  MPRFLYLCLGLLLVRVSRELNDISRARRLCGQHLLHEIVKLCGDVNWSHVEKEKPFTQLLSQASEKVESFIPDRSESSQTTFPVWRRATNPVPTSASQEEAINNMKMQSLPEYQYKKANLPFKTRQEESSSSQDISPYIHEIIEFQKKNTNKIKTLSNLFWGNHPQRKRRGYSEKCCQKGCTKEELIIACLPYIDYENLRKHQQL
  • Signal peptide:  MPRFLYLCLGLLLVRVSRE
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May have a role in sperm development and fertilization.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  45819
  • Structure ID:  AF-Q32L79-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006457_AF2.pdbhor006457_ESM.pdb

Physical Information

Mass: 382748 Formula: C145H228N34O47S4
Absent amino acids: FHMRVW Common amino acids: CE
pI: 4.3 Basic residues: 3
Polar residues: 12 Hydrophobic residues: 7
Hydrophobicity: -25.17 Boman Index: -3285
Half-Life / Aliphatic Index: 30 hour Aliphatic Index: 84.14
Instability Index: 5615.86 Extinction Coefficient cystines: 4720
Absorbance 280nm: 168.57

Literature

  • PubMed ID:  NA
  • Title:  NA