General Information

  • ID:  hor006424
  • Uniprot ID:  P35807
  • Protein name:  Adipokinetic prohormone type 2
  • Gene name:  NA
  • Organism:  Schistocerca nitens (Vagrant locust) (Gray bird grasshopper)
  • Family:  AKH/HRTH/RPCH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Schistocerca (genus), Cyrtacanthacridinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007629 flight behavior
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QLNFSTGWGRRYADPNADPMAFLYKLIQIEARKLAGCSN
  • Length:  39(23-61)
  • Propeptide:  MRQGCALTLMLLVVVCAALSAAQLNFSTGWGRRYADPNADPMAFLYKLIQIEARKLAGCSN
  • Signal peptide:  MRQGCALTLMLLVVVCAALSAA
  • Modification:  T1 Pyrrolidone carboxylic acid;T8 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  37-37
  • Structure ID:  AF-P35807-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006424_AF2.pdbhor006424_ESM.pdb

Physical Information

Mass: 509504 Formula: C197H304N56O56S2
Absent amino acids: HV Common amino acids: A
pI: 9.27 Basic residues: 5
Polar residues: 12 Hydrophobic residues: 14
Hydrophobicity: -41.79 Boman Index: -6745
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 72.82
Instability Index: 2683.33 Extinction Coefficient cystines: 8480
Absorbance 280nm: 223.16

Literature

  • PubMed ID:  2294116
  • Title:  The structurally similar neuropeptides adipokinetic hormone I and II are derived from similar, very small mRNAs.
  • PubMed ID:  3947348
  • Title:  Sequence analyses of adipokinetic hormones II from corpora cardiaca of Schistocerca nitans, Schistocerca gregaria, and Locusta migratoria by