General Information

  • ID:  hor006340
  • Uniprot ID:  Q9VT52
  • Protein name:  Probable insulin-like peptide 3
  • Gene name:  Ilp3
  • Organism:  Drosophila melanogaster (Fruit fly)
  • Family:  Insulin family
  • Source:  Animal
  • Expression:  Expressed in the larva, but not in the embryo. |Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   melanogaster subgroup , melanogaster group , Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae , Schizophora , Cyclorrhapha , Eremoneura , Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta (class), Hexapoda (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005158 insulin receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0007623 circadian rhythm; GO:0008286 insulin receptor signaling pathway; GO:0009743 response to carbohydrate; GO:0030431 sleep; GO:0045475 locomotor rhythm; GO:0060180 female mating behavior; GO:0061964 negative regulation of entry into reproductive diapause
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  TMKLCGRKLPETLSKLCVYGFNAMTKRTLDPVNFNQIDGFEDRSLLERLLSDSSVQMLKTRRLRDGVFDECCLKSCTMDEVLRYCAAKPRT
  • Length:  91(30-120)
  • Propeptide:  MGIEMRCQDRRILLPSLLLLILMIGGVQATMKLCGRKLPETLSKLCVYGFNAMTKRTLDPVNFNQIDGFEDRSLLERLLSDSSVQMLKTRRLRDGVFDECCLKSCTMDEVLRYCAAKPRT
  • Signal peptide:  MGIEMRCQDRRILLPSLLLLILMIGGVQA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  InR
  • Target Unid:  P09208
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  5-72; 17-85; 71-76
  • Structure ID:  AF-Q9VT52-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006340_AF2.pdbhor006340_ESM.pdb

Physical Information

Mass: 1207775 Formula: C450H744N130O136S10
Absent amino acids: HW Common amino acids: L
pI: 8.61 Basic residues: 16
Polar residues: 28 Hydrophobic residues: 26
Hydrophobicity: -35.05 Boman Index: -21062
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 79.23
Instability Index: 4342.09 Extinction Coefficient cystines: 3355
Absorbance 280nm: 37.28

Literature

  • PubMed ID:  10731132
  • Title:  The genome sequence of Drosophila melanogaster.
  • PubMed ID:  12537572
  • Title:  Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
  • PubMed ID:  11250149
  • Title:  An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.