General Information

  • ID:  hor006311
  • Uniprot ID:  Q8CHK2
  • Protein name:  Relaxin-3 A chain
  • Gene name:  Rln3
  • Organism:  Mus musculus (Mouse)
  • Family:  Insulin family
  • Source:  animal
  • Expression:  High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DVLAGLSSSCCEWGCSKSQISSLC
  • Length:  24(118-141)
  • Propeptide:  MAMLGLLLLASWALLGALGLQAEARPAPYGVKLCGREFIRAVIFTCGGSRWRRADILAHESLGDFFADGEANTDHLASELDEAVGSSEWLALTKSPQAFYGGRASWQGSPGVVRGSRDVLAGLSSSCCEWGCSKSQISSLC
  • Signal peptide:  MAMLGLLLLASWALLGALGLQAEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Rxfp3, Rxfp1
  • Target Unid:  Q8BGE9, Q6R6I7
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45945
  • Structure ID:  AF-Q8CHK2-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006311_AF2.pdbhor006311_ESM.pdb

Physical Information

Mass: 287423 Formula: C100H163N27O37S4
Absent amino acids: FHMNPRTY Common amino acids: S
pI: 4.18 Basic residues: 1
Polar residues: 13 Hydrophobic residues: 7
Hydrophobicity: 42.5 Boman Index: -1556
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 81.25
Instability Index: 4468.33 Extinction Coefficient cystines: 5750
Absorbance 280nm: 250

Literature

  • PubMed ID:  12686464
  • Title:  Production of recombinant human relaxin 3 in AtT20 cells.
  • PubMed ID:  11689565
  • Title:  Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family.