HORDB

ID: hor006241
Uniprot ID: P84383
Protein name: Antimicrobial peptide 3
Gene name: NA
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Family: Gastrin/cholecystokinin family
Source: Animal
Expression: Skin.
Disease: NA
Comments: NA
Taxonomy: Silurana (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0003674 molecular_function
GO BP: GO:0006952 defense response; GO:0042742 defense response to bacterium; GO:0050829 defense response to Gram-negative bacterium; GO:0050830 defense response to Gram-positive bacterium
GO CC: GO:0005576 extracellular region

Function: Has antibacterial activity against Gram-positive bacterium S.aureus and Gram-negative bacterium E.coli, when in combination with XT1 and XT6.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P84383-F1.pdb

hor006241_AF2.pdb

hor006241_ESM.pdb

Mass:	292320	Formula:	C116H184N30O31
Absent amino acids:	CDEHIMNRVWY	Common amino acids:	G
pI:	11.1	Basic residues:	3
Polar residues:	8	Hydrophobic residues:	11
Hydrophobicity:	24.8	Boman Index:	346
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	78.4
Instability Index:	2509.2	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 11738090
Title: Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).