General Information

  • ID:  hor006240
  • Uniprot ID:  P84190
  • Protein name:  Hypotensin-2
  • Gene name:  NA
  • Organism:  Tityus serrulatus (Brazilian scorpion)
  • Family:  Non-disulfide-bridged peptide (NDBP) superfamily
  • Source:  animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Tityus (genus), Buthidae (family), Buthoidea (superfamily), Buthida (parvorder), Scorpiones (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AEIDFSGIPEDIIKEIKETNAKPPA
  • Length:  25
  • Propeptide:  AEIDFSGIPEDIIKEIKETNAKPPA
  • Signal peptide:  NA
  • Modification:  T6 Phosphoserine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Agonist of the B2 bradykinin receptor (BDKRB2). Potentiates the hypotensive effect of bradykinin (BK) and induces a direct vasorelaxing effect, independently of BK, by endothelium- and nitric oxide (NO)-dependent mechanisms in rat aortic ring preparations. Does not inhibit the angiotensin-converting enzyme (ACE).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P84190-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P84190-F1.pdbhor006240_AF2.pdbhor006240_ESM.pdb

Physical Information

Mass: 315435 Formula: C122H197N29O41
Absent amino acids: CHLMQRVWY Common amino acids: I
pI: 4.1 Basic residues: 3
Polar residues: 4 Hydrophobic residues: 9
Hydrophobicity: -48.8 Boman Index: -3999
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 90
Instability Index: 3168.8 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  18445483
  • Title:  Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.
  • PubMed ID:  23731212
  • Title:  Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus.
  • PubMed ID:  19689419
  • Title:  Tityus serrulatus scorpion venom and toxins: an overview.