HORDB

ID: hor006239
Uniprot ID: P84189
Protein name: Hypotensin-1
Gene name: NA
Organism: Tityus serrulatus (Brazilian scorpion)
Family: Non-disulfide-bridged peptide (NDBP) superfamily
Source: animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Tityus (genus), Buthidae (family), Buthoidea (superfamily), Buthida (parvorder), Scorpiones (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism
GO CC: GO:0005576 extracellular region

Sequence: AEIDFSGIPEDIIKQIKETNAKPPA
Length: 25
Propeptide: MKMMIPVIFSILLLIFSLSSTAMSLEDEQENMEERAEIDFSGIPEDIIKQIKETNAKPPARFDPAAFEKSDD
Signal peptide: MKMMIPVIFSILLLIFSLSSTAMS
Modification: T6 Phosphoserine
Glycosylation: NA
Mutagenesis: NA

Function: Agonist of the B2 bradykinin receptor (BDKRB2) (PubMed:18445483, PubMed:20417225). Potentiates the hypotensive effect of bradykinin (BK) and induces a direct vasorelaxing effect independent of BK, by endothelium- and nitric oxide (NO)-dependent mechanisms in rat aortic ring preparations (PubMed:18445483, PubMed:20417225). Also exerts proangiogenic, antiinflammatory, and antifibrogenic activities (PubMed:27732900).
Mechanism: Negative results: does not inhibit the angiotensin-converting enzyme (ACE).
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006239_AF2.pdb

hor006239_ESM.pdb

Mass:	315337	Formula:	C122H198N30O40
Absent amino acids:	CHLMRVWY	Common amino acids:	I
pI:	4.26	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	9
Hydrophobicity:	-48.8	Boman Index:	-3872
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	90
Instability Index:	3345.6	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 29561852
Title: Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions.
PubMed ID: 33181162
Title: Novel components of Tityus serrulatus venom: A transcriptomic approach.
PubMed ID: 18445483
Title: Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.
PubMed ID: 18718845
Title: Tityus serrulatus venom peptidomics: assessing venom peptide diversity.
PubMed ID: 20417225
Title: Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): A new agonist of B(2) kinin receptor.
PubMed ID: 23731212
Title: Moving pieces in a venomic puzzle: unveiling post-translationally modified toxins from Tityus serrulatus.
PubMed ID: 27732900
Title: Ts14 from Tityus serrulatus boosts angiogenesis and attenuates inflammation and collagen deposition in sponge-induced granulation tissue in mice.
PubMed ID: 19689419
Title: Tityus serrulatus scorpion venom and toxins: an overview.