HORDB

ID: hor006235
Uniprot ID: P70664
Protein name: Guanylin
Gene name: GUCA2A
Organism: Cavia porcellus (Guinea pig)
Family: Guanylin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Cavia (genus), Caviidae (family), Hystricomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0030250 guanylate cyclase activator activity
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: PSTCEICAYAACAGC
Length: 15(93-107)
Propeptide: MNTFLLSALCLGAWAALVGAVTVQDGDFSFSLESVKKLKDLQEAPESKVQGRRKFVAPPLCSFSGFPEELRPVCKEPNSQDILNRLAVIAQDPSTCEICAYAACAGC
Signal peptide: MNTFLLSALCLGAWAALVGA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006235_AF2.pdb

hor006235_ESM.pdb

Mass:	171261	Formula:	C58H91N15O21S4
Absent amino acids:	DFHKLMNQRVW	Common amino acids:	AC
pI:	3.85	Basic residues:	0
Polar residues:	8	Hydrophobic residues:	5
Hydrophobicity:	89.33	Boman Index:	530
Half-Life:	>20 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	?	Aliphatic Index	52.67
Instability Index:	8009.33	Extinction Coefficient cystines:	1740
Absorbance 280nm:	124.29