General Information

  • ID:  hor006233
  • Uniprot ID:  P57672
  • Protein name:  Vespulakinin-2
  • Gene name:  NA
  • Organism:  Vespula maculifrons (Eastern yellow jacket) (Wasp)
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Vespula (genus), Vespinae (subfamily), Vespidae (family), Vespoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta (class), Hexapoda (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TTRRRGRPPGFSPFR
  • Length:  15(3-17)
  • Propeptide:  TATTRRRGRPPGFSPFR
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  T1 O-linked (GalNAc...) threonine;T2 O-linked (GalNAc...) threonine
  • Mutagenesis:  NA

Activity

  • Function:  Induces smooth muscle contraction. May target bradykinin receptors (BDKRB). May cause hypotension.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P57672-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006233_AF2.pdbhor006233_ESM.pdb

Physical Information

Mass: 203790 Formula: C78H126N30O19
Absent amino acids: ACDEHIKLMNQVWY Common amino acids: R
pI: 13.1 Basic residues: 5
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: -164.67 Boman Index: -7530
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 14786 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1247511
  • Title:  Vespulakinins: new carbohydrate-containing bradykinin derivatives.
  • PubMed ID:  3679673
  • Title:  Synthesis, conformation, and biological activity of the carbohydrate-free vespulakinin 1.