General Information

  • ID:  hor006229
  • Uniprot ID:  P55936
  • Protein name:  Guanylin
  • Gene name:  GUCA2A
  • Organism:  Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
  • Family:  Guanylin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Didelphis (genus), Didelphinae (subfamily), Didelphidae (family), Didelphimorphia (order), Metatheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SHTCEICAFAACAGC
  • Length:  15(1-15)
  • Propeptide:  SHTCEICAFAACAGC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  4-12; 7-15
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006229_AF2.pdbhor006229_ESM.pdb

Physical Information

Mass: 173664 Formula: C59H91N17O20S4
Absent amino acids: DKLMNPQRVWY Common amino acids: AC
pI: 5.35 Basic residues: 1
Polar residues: 7 Hydrophobic residues: 6
Hydrophobicity: 106 Boman Index: 376
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 52.67
Instability Index: 4644 Extinction Coefficient cystines: 250
Absorbance 280nm: 17.86

Literature

  • PubMed ID:  7902563
  • Title:  Uroguanylin: structure and activity of a second endogenous peptide that stimulates intestinal guanylate cyclase.