General Information

  • ID:  hor006222
  • Uniprot ID:  P51456
  • Protein name:  Relaxin-like protein SQ10 A chain
  • Gene name:  NA
  • Organism:  Oryctolagus cuniculus (Rabbit)
  • Family:  Insulin family
  • Source:  Animal
  • Expression:  During squamous cell differentiation. Repressed by retinoic acid.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QFSESLPEECCKYGCPRYYLLMYC
  • Length:  24(155-178)
  • Propeptide:  MPALLFYLLGFCLLQGQVTGRVTYEWMMENVKICRNDFVRTAIEVCGHVHLERESPSPENPFLSSGPAAETVPSSIKKDAENANTMLESIPNLPQELTATLFEKQPSKLYLQYLPTLKKSNVSFEEFKKIIQNIQRGVQGSSASESNTFSRKKRQFSESLPEECCKYGCPRYYLLMYC
  • Signal peptide:  MPALLFYLLGFCLLQGQVTG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  RXFP2, RXFP1
  • Target Unid:  G1SDZ8, A0A0M3SGA3
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45945
  • Structure ID:  AF-P51456-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006222_AF2.pdbhor006222_ESM.pdb

Physical Information

Mass: 333682 Formula: C130H189N29O38S5
Absent amino acids: ADHINTVW Common amino acids: CY
pI: 4.48 Basic residues: 2
Polar residues: 11 Hydrophobic residues: 4
Hydrophobicity: -27.92 Boman Index: -2765
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 48.75
Instability Index: 8286.25 Extinction Coefficient cystines: 6210
Absorbance 280nm: 270

Literature

  • PubMed ID:  1339318
  • Title:  Expression of a preprorelaxin-like gene during squamous differentiation of rabbit tracheobronchial epithelial cells and its suppression by retinoic acid.