General Information

  • ID:  hor006211
  • Uniprot ID:  P42992
  • Protein name:  Neurophysin VT
  • Gene name:  NA
  • Organism:  Sclerophrys regularis (Common African toad) (Bufo regularis)
  • Family:  Vasopressin/oxytocin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sclerophrys (genus), Bufonidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SYPDTAVPQCIPCGP
  • Length:  15(13-27)
  • Propeptide:  CYIQNCPRGGKRSYPDTAVPQCIPCGP
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Vasotocin is an antidiuretic hormone.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P42992-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006211_AF2.pdbhor006211_ESM.pdb

Physical Information

Mass: 179766 Formula: C67H102N16O22S2
Absent amino acids: EFHKLMNRW Common amino acids: P
pI: 3.75 Basic residues: 0
Polar residues: 6 Hydrophobic residues: 3
Hydrophobicity: -7.33 Boman Index: -610
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 52
Instability Index: 1622 Extinction Coefficient cystines: 1615
Absorbance 280nm: 115.36

Literature

  • PubMed ID:  8097151
  • Title:  Vasotocin and hydrin 2 (vasotocinyl-Gly) in the African toad Bufo regularis: study under various environmental conditions.