HORDB

ID: hor006191
Uniprot ID: P31241
Protein name: Molluscan insulin-related peptide 5 B chain
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: Animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila , Panpulmonata , Euthyneura , Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa , Spiralia , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: QFSACSFSSRPHPRGICGSDLADLRAFICSRRNQPAMV
Length: 38(32-69)
Propeptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEGQFSACSFSSRPHPRGICGSDLADLRAFICSRRNQPAMVKRDAETGWLLPETMVKRNAQTDLDDPLRNIKLSSESALTYLTKRQRTTNLVCECCYNVCTVDVFYEYCY
Signal peptide: MAGVRLVFTKAFMVTVLLTLLLNIGVKPAEG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006191_AF2.pdb

hor006191_ESM.pdb

Mass:	484292	Formula:	C177H282N58O52S4
Absent amino acids:	EKTWY	Common amino acids:	S
pI:	9	Basic residues:	6
Polar residues:	12	Hydrophobic residues:	12
Hydrophobicity:	-20.53	Boman Index:	-8685
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	59.21
Instability Index:	6168.68	Extinction Coefficient cystines:	125
Absorbance 280nm:	3.38

PubMed ID: 1323019
Title: Characterization of a cDNA clone encoding molluscan insulin-related peptide V of Lymnaea stagnalis.