HORDB

ID: hor006143
Uniprot ID: P23389
Protein name: Secretolytin
Gene name: CHGB
Organism: Bos taurus (Bovine)
Family: Chromogranin/secretogranin protein family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030658 transport vesicle membrane; GO:0031410 cytoplasmic vesicle

Sequence: DLELQKIAEKFSGTRRG
Length: 17(630-646)
Propeptide: MQPAALLGLLGATVVAAVSSMPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESGGHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQTAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHPEGQEAPGESEEDASP
Signal peptide: MQPAALLGLLGATVVAAVSS
Modification: T5 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites.; Secretolytin has ant
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006143_AF2.pdb

hor006143_ESM.pdb

Mass:	223378	Formula:	C84H142N26O27
Absent amino acids:	CHMNPVWY	Common amino acids:	EGKLR
pI:	9.53	Basic residues:	4
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-96.47	Boman Index:	-5336
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	74.71
Instability Index:	4730	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2025642
Title: Primary structure of bovine chromogranin B deduced from cDNA sequence.
PubMed ID: 9136897
Title: Identification of the secretory vesicle membrane binding region of chromogranin B.
PubMed ID: 1350945
Title: Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin
PubMed ID: 8218367
Title:
PubMed ID: 1554736
Title:
PubMed ID: 1982622
Title:
PubMed ID: 7744058
Title:
PubMed ID: 15174145
Title:
PubMed ID: 8603705
Title: