HORDB

ID: hor006119
Uniprot ID: P13211
Protein name: Sarafotoxin-D
Gene name: NA
Organism: Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Family: Endothelin/sarafotoxin family
Source: Animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Atractaspis (genus), Atractaspidinae (subfamily), Lamprophiidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera , Episquamata , Unidentata , Bifurcata , Squamata (order), Lepidosauria (class), Sauria , Sauropsida , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0019229 regulation of vasoconstriction; GO:0035821 modulation of process of another organism; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P13211-F1.pdb

hor006119_AF2.pdb

hor006119_ESM.pdb

Mass:	295297	Formula:	C112H167N27O34S5
Absent amino acids:	AGNPRSV	Common amino acids:	C
pI:	4.49	Basic residues:	3
Polar residues:	7	Hydrophobic residues:	5
Hydrophobicity:	-21.9	Boman Index:	-3201
Half-Life / Aliphatic Index:	1.2 hour	Aliphatic Index:	55.71
Instability Index:	7442.38	Extinction Coefficient cystines:	7240
Absorbance 280nm:	362