General Information

  • ID:  hor006091
  • Uniprot ID:  O62827
  • Protein name:  Proadrenomedullin N-20 terminal peptide
  • Gene name:  ADM
  • Organism:  Bos taurus (Bovine)
  • Family:  Adrenomedullin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0031700 adrenomedullin receptor binding
  • GO BP:  GO:0003073 regulation of systemic arterial blood pressure; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0010460 positive regulation of heart rate; GO:1990410 adrenomedullin receptor signaling pathway
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  ARLDVAAEFRKKWNKWALSR
  • Length:  16(105-120)
  • Propeptide:  MKLVPVALLYLGSLAFLGVDTARLDVAAEFRKKWNKWALSRGKRELRESSSYPTGLADVKAGPVQTLIRPQDVKGASRSPQASSPDAARIRVKRYRQSLNNFQGLRSFGCRFGTCTVQKLAHQIYHFTDKDKDGSAPRSKISPQGYGRRRRRSLPEAGLGRTLLQPPEPKLRGAPDSRVHQVLATLRI
  • Signal peptide:  MKLVPVALLYLGSLAFLGVDT
  • Modification:  T20 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hypotensive peptide. May function as a hormone in circulation control (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O62827-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006091_AF2.pdbhor006091_ESM.pdb

Physical Information

Mass: 278494 Formula: C112H177N35O27
Absent amino acids: CGHIMPQTY Common amino acids: A
pI: 11.65 Basic residues: 6
Polar residues: 2 Hydrophobic residues: 10
Hydrophobicity: -82.5 Boman Index: -5822
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 73.5
Instability Index: 2962.5 Extinction Coefficient cystines: 11000
Absorbance 280nm: 578.95

Literature

  • PubMed ID:  9585168
  • Title:  Cloning of bovine preproadrenomedullin and inhibition of its basal expression in vascular endothelial cells by staurosporine.
  • PubMed ID:  11754956
  • Title:  Adrenomedullin (11-26): a novel endogenous hypertensive peptide isolated from bovine adrenal medulla.