General Information

  • ID:  hor006085
  • Uniprot ID:  O46201
  • Protein name:  Accessory gland protein 98AB
  • Gene name:  Acp98AB
  • Organism:  Drosophila melanogaster (Fruit fly)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  melanogaster subgroup, melanogaster group, Sophophora (subgenus), Drosophila (genus), Drosophilini (tribe), Drosophilinae (subfamily), Drosophilidae (family), Ephydroidea (superfamily), Acalyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0007610 behavior; GO:0019953 sexual reproduction; GO:0045434 negative regulation of female receptivity, post-mating
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  RIRGHTIKG
  • Length:  9(17-25)
  • Propeptide:  MKLLILFLAALGAASARIRGHTIKG
  • Signal peptide:  MKLLILFLAALGAASA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Responsible for physiological and behavioral changes in mated female flies.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O46201-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006085_AF2.pdbhor006085_ESM.pdb

Physical Information

Mass: 118011 Formula: C44H80N18O11
Absent amino acids: ACDEFLMNPQSVWY Common amino acids: GIR
pI: 12.52 Basic residues: 4
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -95.56 Boman Index: -3090
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 86.67
Instability Index: -2778.89 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  9474779
  • Title:  New genes for male accessory gland proteins in Drosophila melanogaster.
  • PubMed ID:  11102381
  • Title:  Molecular population genetics of male accessory gland proteins in Drosophila.
  • PubMed ID:  10731132
  • Title:  The genome sequence of Drosophila melanogaster.
  • PubMed ID:  12537572
  • Title:  Annotation of the Drosophila melanogaster euchromatic