HORDB

ID: hor006063
Uniprot ID: Q9HCQ7
Protein name: Neuropeptide RFRP-2
Gene name: NPVF
Organism: Homo sapiens (Human)
Family: FARP (FMRFamide related peptide) family
Source: Human
Expression: Isoform 1 is specifically expressed in the retina. Neuropeptides RFRP-1 and NPVF are detected in the hypothalamus.
Disease: Diseases associated with NPVF include Precocious Puberty, Central, 1.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005515 protein binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032277 negative regulation of gonadotropin secretion
GO CC: GO:0005576 extracellular region

Sequence: SAGATANLPLRS
Length: 12(101-112)
Propeptide: MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSLVRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSRRLLFKKIDDAELKQEK
Signal peptide: MEIISSKLFILLTLATSSLLTSNIFC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces sec
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006063_AF2.pdb

hor006063_ESM.pdb

Mass:	135368	Formula:	C48H84N16O17
Absent amino acids:	CDEFHIKMQVWY	Common amino acids:	A
pI:	10.55	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	5
Hydrophobicity:	5.83	Boman Index:	-1472
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	90
Instability Index:	7080.83	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 11025660
Title: New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.
PubMed ID: 11481330
Title: Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.
PubMed ID: 11951088
Title: Genomic structure and assessment o
PubMed ID: 12853948
Title:
PubMed ID: 12690205
Title:
PubMed ID: 20027225
Title: