HORDB

General Information

ID: hor006061
Uniprot ID: Q8CH01
Protein name: Hemokinin
Gene name: Tac4
Organism: Rattus norvegicus (Rat)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0031835 substance P receptor binding; GO:0031837 substance K receptor binding; GO:0048018 receptor ligand activity
GO BP: GO:0003085 negative regulation of systemic arterial blood pressure; GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0008217 regulation of blood pressure; GO:0043303 mast cell degranulation; GO:0046878 positive regulation of saliva secretion; GO:0050965 detection of temperature stimulus involved in sensory perception of pain; GO:0051930 regulation of sensory perception of pain; GO:1902093 positive regulation of flagellated sperm motility; GO:1904057 negative regulation of sensory perception of pain
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

Sequence: SRTRQFYGLM
Length: 10(57-66)
Propeptide: MLPLLALFLLIGPAVSTTTRDREDLTFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVEGVHPIQSAERTGYQLGRIVQDLLGTRGLSIEGSCRQETNHQSAGPGAVARESLQSQRGRSEPPNHQQHVALSLGTEEDDQSSERAPRDASQMMPRPSRP
Signal peptide: MLPLLALFLLIGPAVS
Modification: T10 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle
Mechanism: NA
Cross BBB: NA
Target: Tacr1
Target Unid: P14600
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-Q8CH01-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006061_AF2.pdb

hor006061_ESM.pdb

Physical Information

Mass:	141916	Formula:	C55H87N17O15S
Absent amino acids:	ACDEHIKNPVW	Common amino acids:	R
pI:	11.15	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	2
Hydrophobicity:	-72	Boman Index:	-3030
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	39
Instability Index:	6409	Extinction Coefficient cystines:	1490
Absorbance 280nm:	165.56

Literature

PubMed ID: 12383518
Title: Identification, localization and receptor characterization of novel mammalian substance P-like peptides.
PubMed ID: 11786503
Title: Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.
PubMed ID: 12044836
Title: Pharmacological profile of hemokinin 1: a novel member of the tachykinin fam
PubMed ID: 16102736
Title:
PubMed ID: 17628523
Title: