HORDB

ID: hor006049
Uniprot ID: Q6ECK6
Protein name: Endokinin-2
Gene name: TAC4
Organism: Oryctolagus cuniculus (Rabbit)
Family: Tachykinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Oryctolagus (genus), Leporidae (family), Lagomorpha (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: GO:1902093 positive regulation of flagellated sperm motility
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: VRGYQMGQRGLL
Length: 12(71-82)
Propeptide: MPSSVTLLLLMGLSVCTSAEDGGEEQTLGAEAGPWVTVTLEAGAVASIQLQLQEVKRGKASQFFGLMGKRVRGYQMGQRGLLGRRASSTKGSVDEDQGAE
Signal peptide: MPSSVTLLLLMGLSVCTSA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Mechanism: NA
Cross BBB: NA
Target: TACR1, TACR2
Target Unid: G1SEI7, P79218
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006049_AF2.pdb

hor006049_ESM.pdb

Mass:	157402	Formula:	C59H100N20O16S
Absent amino acids:	ACDEFHIKNPSTW	Common amino acids:	G
pI:	11.15	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-40	Boman Index:	-2201
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	89.17
Instability Index:	-1205.83	Extinction Coefficient cystines:	1490
Absorbance 280nm:	135.45