General Information

  • ID:  hor006030
  • Uniprot ID:  Q10581
  • Protein name:  Angiotensin-like peptide 1
  • Gene name:  NA
  • Organism:  Bothrops jararaca (Jararaca) (Bothrops jajaraca)
  • Family:  Serpin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Bothrops (genus), Crotalinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera , Episquamata , Unidentata , Bifurcata , Squamata (order), Lepidosauria (class), Sauria , Sauropsida , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
  • GO CC:  NA

Sequence Information

  • Sequence:  DRVYVHPFYL
  • Length:  10(1-10)
  • Propeptide:  DRVYVHPFYL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006030_AF2.pdbhor006030_ESM.pdb

Physical Information

Mass: 146921 Formula: C64H89N15O15
Absent amino acids: ACEGIKMNQSTW Common amino acids: VY
pI: 7.54 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -4 Boman Index: -1260
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 97
Instability Index: 4290 Extinction Coefficient cystines: 2980
Absorbance 280nm: 331.11

Literature

  • PubMed ID:  8829801
  • Title:  Isolation and identification of angiotensin-like peptides from the plasma of the snake Bothrops jararaca.