HORDB

ID: hor006014
Uniprot ID: P84900
Protein name: Phyllokininogen-1
Gene name: NA
Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)
Family: Frog skin active peptide (FSAP) family, Bradykinin-related peptide subfamily
Source: animal
Expression: Expressed by the skin glands.
Disease: NA
Comments: NA
Taxonomy: Pithecopus (genus), Phyllomedusinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0006952 defense response; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006014_AF2.pdb

hor006014_ESM.pdb

Mass:	558082	Formula:	C206H312N56O82
Absent amino acids:	CHLMQTVW	Common amino acids:	E
pI:	3.9	Basic residues:	7
Polar residues:	6	Hydrophobic residues:	5
Hydrophobicity:	-225.75	Boman Index:	-20307
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	22
Instability Index:	14599	Extinction Coefficient cystines:	1490
Absorbance 280nm:	38.21

PubMed ID: 16713656
Title: Elements of the granular gland peptidome and transcriptome persist in air-dried skin of the South American orange-legged leaf frog, Phyllomedusa hypocondrialis.
PubMed ID: 16797783
Title: Bradykinin-related peptides from Phyllomedusa hypochondrialis.
PubMed ID: 17120273
Title: Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs.