HORDB

ID: hor006012
Uniprot ID: P84898
Protein name: bradykinyl-Val
Gene name: NA
Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)
Family: Bradykinin-related peptide family
Source: Animal
Expression: Expressed by the skin glands.
Disease: NA
Comments: NA
Taxonomy: Pithecopus (genus), Phyllomedusinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0090729 toxin activity
GO BP: GO:0006952 defense response; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Function: Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006012_AF2.pdb

hor006012_ESM.pdb

Mass:	140995	Formula:	C59H86N14O15
Absent amino acids:	ACEHIKLMNQSWY	Common amino acids:	P
pI:	6.34	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	4
Hydrophobicity:	0.91	Boman Index:	-1123
Half-Life:	100 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	52.73
Instability Index:	4795.45	Extinction Coefficient cystines:	0
Absorbance 280nm:	0