General Information

  • ID:  hor006003
  • Uniprot ID:  P82092
  • Protein name:  Caerulein-4.2/4.2Y4
  • Gene name:  NA
  • Organism:  Ranoidea citropa (Australian Blue Mountains tree frog) (Litoria citropa)
  • Family:  Gastrin/cholecystokinin family
  • Source:  Animal
  • Expression:  Expressed by the skin dorsal glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Ranoidea (genus), Pelodryadinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0008217 regulation of blood pressure
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QQDYTGSHFDF
  • Length:  11(1-11)
  • Propeptide:  QQDYTGSHFDF
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T4 Sulfotyrosine;T11 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hypotensive neuropeptide.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006003_AF2.pdbhor006003_ESM.pdb

Physical Information

Mass: 152291 Formula: C60H77N15O21
Absent amino acids: ACEIKLMNPRVW Common amino acids: DFQ
pI: 4.11 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -134.55 Boman Index: -3239
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 2360.91 Extinction Coefficient cystines: 1490
Absorbance 280nm: 149

Literature

  • PubMed ID:  10589099
  • Title:  Caerulein-like peptides from the skin glands of the Australian Blue Mountains tree frog Litoria citropa. Part 1. Sequence determination using electrospray mass spectrometry.