General Information

  • ID:  hor005997
  • Uniprot ID:  P81796
  • Protein name:  Neurotensin
  • Gene name:  NA
  • Organism:  Rhinella marina (Cane toad) (Bufo marinus)
  • Family:  Neurotensin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Rhinella (genus), Bufonidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QAIVSKARRPYIL
  • Length:  13(1-13)
  • Propeptide:  QAIVSKARRPYIL
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Smooth muscle-contracting peptide. Peptide action is not affected by tetrodotoxin, but is slightly mediated through the release of acetylcholine.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005997_AF2.pdbhor005997_ESM.pdb

Physical Information

Mass: 172906 Formula: C69H119N21O17
Absent amino acids: CDEFGHMNTW Common amino acids: AIR
pI: 11.53 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: 3.85 Boman Index: -2205
Half-Life / Aliphatic Index: 0.8 hour Aliphatic Index: 127.69
Instability Index: 7639.23 Extinction Coefficient cystines: 1490
Absorbance 280nm: 124.17

Literature

  • PubMed ID:  9786176
  • Title:  Purification, characterization, and spasmogenic activity of neurotensin from the toad Bufo marinus.