HORDB

ID: hor005995
Uniprot ID: P69251
Protein name: Morphogenetic neuropeptide
Gene name: NA
Organism: Hydra vulgaris (Hydra) (Hydra attenuata)
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Hydra (genus), Hydridae (family), Aplanulata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0008083 growth factor activity; GO:0048018 receptor ligand activity
GO BP: GO:0002031 G protein-coupled receptor internalization; GO:0007049 cell cycle; GO:0007218 neuropeptide signaling pathway; GO:0051301 cell division; GO:0090068 positive regulation of cell cycle process
GO CC: GO:0005737 cytoplasm

Function: HA acts as an autocrine growth factor for neural cells in the G2/mitosis transition.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005995_AF2.pdb

hor005995_ESM.pdb

Mass:	132091	Formula:	C54H87N13O14
Absent amino acids:	ACDEHMNRTWY	Common amino acids:	GP
pI:	9.7	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	4
Hydrophobicity:	28.18	Boman Index:	425
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.27
Instability Index:	6511.82	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 16593123
Title: Isolation and amino acid sequence of a morphogenetic peptide from hydra.
PubMed ID: 7297679
Title: Synthesis of a new neuropeptide, the head activator from hydra.