HORDB

ID: hor005987
Uniprot ID: P68515
Protein name: Bradykinin-potentiating peptide S3
Gene name: NA
Organism: Bothrops insularis (Golden lancehead) (Lachesis insularis)
Family: Bradykinin-potentiating peptide family; Natriuretic peptide family
Source: Animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Bothrops (genus), Crotalinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera , Episquamata , Unidentata , Bifurcata , Squamata (order), Lepidosauria (class), Sauria , Sauropsida , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0004857 enzyme inhibitor activity; GO:0005179 hormone activity; GO:0008191 metalloendopeptidase inhibitor activity; GO:0030414 peptidase inhibitor activity; GO:0090729 toxin activity
GO BP: GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region; GO:0005737 cytoplasm; GO:0005829 cytosol

Sequence: QGGWPRPGPEIPP
Length: 13(31-43)
Propeptide: MVLSRLAASGLLLLALLALSVDGKPVQQWAQGGWPRPGPEIPPLKVQQWAQGGWPRPGPEIPPLTVQQWAQNWPHPQIPPLTVQQWAQLGPPPRPQIPPLEVQQWAQGRAPHPPIPPAPLQKWAPVQKWAPLLQPHESPASGTTALREELSLGPEAASGVPSAGAEVGRSGSKAPAAPHRLSKSKGAAATSAASRPMRDLRPDGKQARQNWGRMVHHDHHAAVGGGGGGGGGGARRLKGLAKKGAAKGCFGLKLD
Signal peptide: MVLSRLAASGLLLLALLALSVDG
Modification: T1 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: [Bradykinin-potentiating peptide 5a]: Modestly inhibits ACE (with highest affinity for the N-site) and reveals strong bradykinin-potentiating activity. Induces nitric oxide (NO) production depended on muscarinic acetylcholine receptor M1 subtype (CHRM1) a
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005987_AF2.pdb

hor005987_ESM.pdb

Mass:	160177	Formula:	C64H94N18O17
Absent amino acids:	ACDFHKLMNSTVY	Common amino acids:	P
pI:	6.41	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	2
Hydrophobicity:	-131.54	Boman Index:	-1720
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	30
Instability Index:	7801.54	Extinction Coefficient cystines:	5500
Absorbance 280nm:	458.33

PubMed ID: 12459276
Title: A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs).
PubMed ID: 2386615
Title: Primary structure and biological activity of bradykinin potentiating peptides from Bothrops i
PubMed ID: 15912471
Title:
PubMed ID: 18200607
Title:
PubMed ID: 11994001
Title:
PubMed ID: 17475904
Title:
PubMed ID: 19491403
Title:
PubMed ID: 21185808
Title:
PubMed ID: 22869554
Title: