General Information

  • ID:  hor005982
  • Uniprot ID:  P58396
  • Protein name:  Kinin-like peptide-S
  • Gene name:  NA
  • Organism:  Lycosa erythrognatha (Wolf spider) (Scaptocosa raptoria)
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Lycosa (genus), Lycosidae (family), Lycosoidea (superfamily), RTA clade , Entelegynae , Araneomorphae (suborder), Araneae (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RLVLEVXASVEADV
  • Length:  14(1-14)
  • Propeptide:  RLVLEVXASVEADV
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has kinin-like biological properties. Causes contraction of isolated guinea pig ileum and relaxation of rat duodenum. Has a number of hypotensive properties: decreases arterial blood pressure and increases capillary permeability. Induces edema when inject
  • Mechanism:  The molecular weight of about 4 kDa suggests that the mature peptide comprises about 36 amino acid residues.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005982_AF2.pdbhor005982_ESM.pdb

Physical Information

Mass: 172366 Formula: C61H104N16O20
Absent amino acids: CFGHIKMNPQTWY Common amino acids: V
pI: 3.93 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 8
Hydrophobicity: 87.14 Boman Index: -1104
Half-Life / Aliphatic Index: 1 hour Aliphatic Index: 152.86
Instability Index: 179.29 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  9604280
  • Title:  Isolation, characterization and biological properties of two kinin-like peptides (peptide-S and peptide-r) from Scaptocosa raptoria venom.