General Information

  • ID:  hor005918
  • Uniprot ID:  P05225
  • Protein name:  Caerulein
  • Gene name:  NA
  • Organism:  Xenopus laevis (African clawed frog)
  • Family:  Gastrin/cholecystokinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0006952 defense response; GO:0007165 signal transduction; GO:0007586 digestion
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QQDYTGWMDF
  • Length:  10(10-19)
  • Propeptide:  NDERRFADGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAALKIGANALGGSLQQREVNDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVHERDVRGFGSFLGKAL
  • Signal peptide:  NA
  • Modification:  T4 Sulfotyrosine;T10 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  The pharmacological activities of caerulein are quite similar to the physiological activities of gastrin and related peptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P05225-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005918_AF2.pdbhor005918_ESM.pdb

Physical Information

Mass: 145109 Formula: C58H75N13O19S
Absent amino acids: ACEHIKLNPRSV Common amino acids: DQ
pI: 3.49 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -126 Boman Index: -2263
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 5902 Extinction Coefficient cystines: 6990
Absorbance 280nm: 776.67

Literature

  • PubMed ID:  6526274
  • Title:  An unusual repetitive structure of caerulein mRNA from the skin of Xenopus laevis.
  • PubMed ID:  5413288
  • Title:  Presence of caerulein in extracts of the skin of Leptodactylus pentadactylus labyrinthicus and of Xenopus laevis.