General Information

  • ID:  hor005908
  • Uniprot ID:  P01016
  • Protein name:  Angiotensinogen
  • Gene name:  AGT
  • Organism:  Equus caballus (Horse)
  • Family:  Serpin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Equus (genus), Equidae (family), Perissodactyla (order), Laurasiatheria (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DRVYIHPFHLLVYS
  • Length:  14(1-14)
  • Propeptide:  DRVYIHPFHLLVYS
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005908_AF2.pdbhor005908_ESM.pdb

Physical Information

Mass: 199110 Formula: C85H123N21O20
Absent amino acids: ACEGKMNQTW Common amino acids: HLVY
pI: 7.7 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 6
Hydrophobicity: 27.86 Boman Index: -1082
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 125
Instability Index: 1364.29 Extinction Coefficient cystines: 2980
Absorbance 280nm: 229.23

Literature

  • PubMed ID:  13463253
  • Title:  The preparation, purification, and amino acid sequence of a polypeptide renin substrate.