General Information

  • ID:  hor005820
  • Uniprot ID:  P84814
  • Protein name:  Opioid peptide
  • Gene name:  NA
  • Organism:  Amblyomma testudinarium (Hard tick)
  • Family:  NA
  • Source:  Animal
  • Expression:  Expressed in the synganglia (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Amblyomma (genus), Amblyomminae (subfamily), Ixodidae (family), Ixodoidea (superfamily), Ixodida (order), Parasitiformes (superorder), Acari (subclass), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0001515 opioid peptide activity
  • GO BP:  GO:0007165 signal transduction; GO:0051930 regulation of sensory perception of pain
  • GO CC:  GO:0005575 cellular_component

Sequence Information

  • Sequence:  LVVYPWTKM
  • Length:  9(1-9)
  • Propeptide:  LVVYPWTKM
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has opiate-like activity. Decreases nociception-related behavior in a dose dependent fashion when administered to mice. May play a role in down-regulating the host defense and immune response during feeding.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005820_AF2.pdbhor005820_ESM.pdb

Physical Information

Mass: 127929 Formula: C56H85N11O12S
Absent amino acids: ACDEFGHINQRS Common amino acids: V
pI: 9.3 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 63.33 Boman Index: 942
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 107.78
Instability Index: 3054.44 Extinction Coefficient cystines: 6990
Absorbance 280nm: 873.75

Literature

  • PubMed ID:  15752574
  • Title:  An opioid peptide from synganglia of the tick, Amblyomma testindinarium.