HORDB

ID: hor005790
Uniprot ID: P15513
Protein name: Myomodulin H
Gene name: MYOMOD1
Organism: Aplysia californica (California sea hare)
Family: NA
Source: Animal
Expression: Expressed in all ganglia of the CNS, but only in a subset of neurons including L10 in the abdominal ganglion and B16 in the buccal ganglion.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: GLHMLRL
Length: 7(63-69)
Propeptide: MQVYMLLPLAVFASLTYQGACEETAAAQTSSDASTSSASSEHAENELSRAKRGSYRMMRLGRGLHMLRLGKRGGPVEPESEENLETLLNLLQGYYSDVPEYPSEFDDTDLAYPYEEYDAPAHPRYRRSTPPTDGVVAPDVLQKGSSEFEDFGDSQLDESDEGYYGYDPENYLYGDFEDYLEPEEGGLGEEKRSLSMLRLGKRGLSMLRLGKREGEEGDEMDKKQDESLNDDFENDDIKRTLSMLRLGKRPMSMLR
Signal peptide: MQVYMLLPLAVFASLTYQ
Modification: T7 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Function: Exogenous application of myomodulins potentiates ARC muscle contraction.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005790_AF2.pdb

hor005790_ESM.pdb

Mass:	94628	Formula:	C37H66N12O8S
Absent amino acids:	ACDEFIKNPQSTVWY	Common amino acids:	L
pI:	10.55	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	74.29	Boman Index:	-153
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	167.14
Instability Index:	3608.57	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 8422272
Title: Molecular cloning of myomodulin cDNA, a neuropeptide precursor gene expressed in neuron L10 of Aplysia californica.
PubMed ID: 8340812
Title: The myomodulin-related neuropeptides: characterization of a gene encoding a family of peptide cotransmitters in Aplysia.
PubMed ID: 1788132
Title: Structure, bioac
PubMed ID: 7472354
Title:
PubMed ID: 3474664
Title: