HORDB

ID: hor005743
Uniprot ID: O44663
Protein name: GMW-amide
Gene name: nlp-30
Organism: Caenorhabditis elegans
Family: YARP (YGGW-amide related peptide) family
Source: animal
Expression: Upon D.coniospora infection. |Expressed in hypoderm.
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: RGMW
Length: 4
Propeptide: MISTSSILILVVLLACFMAASAQWGYGGYGRGYGGYGGYGRGYGGYGRGYGGYGRGMWGRPYGGYGWGK
Signal peptide: MISTSSILILVVLLACFMAASA
Modification: T4 Tryptophan amide
Glycosylation: NA
Mutagenesis: NA

Function: May have antimicrobial activity. May play a role in response to fungal infection.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005743_AF2.pdb

hor005743_ESM.pdb

Mass:	60235	Formula:	C24H36N8O5S
Absent amino acids:	ACDEFHIKLNPQSTVY	Common amino acids:	GMRW
pI:	10.55	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	1
Hydrophobicity:	-97.5	Boman Index:	-930
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	0
Instability Index:	-1372.5	Extinction Coefficient cystines:	5500
Absorbance 280nm:	1833.33

PubMed ID: 9851916
Title: Genome sequence of the nematode C. elegans: a platform for investigating biology.
PubMed ID: 11717458
Title: Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species.
PubMed ID: 19380113
Title: Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.