General Information

  • ID:  hor005715
  • Uniprot ID:  Q9PT99
  • Protein name:  Peptide YY-like
  • Gene name:  pyy
  • Organism:  Dicentrarchus labrax (European seabass) (Morone labrax)
  • Family:  NPY family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Dicentrarchus (genus), Moronidae (family), Eupercaria incertae sedis, Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPAKPASPRDGAPPEELAKYYSALRHYINLITRQRY
  • Length:  36(28-63)
  • Propeptide:  MIHSGAVMSMSILAFCLLACIHSGINAYPAKPASPRDGAPPEELAKYYSALRHYINLITRQRYGKRDTPDTVFSDVLMRESTESIPGSNYVRYDGLPLW
  • Signal peptide:  MIHSGAVMSMSILAFCLLACIHSGINA
  • Modification:  T36 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Gastrointestinal hormone and neuropeptide.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9PT99-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005715_AF2.pdbhor005715_ESM.pdb

Physical Information

Mass: 483123 Formula: C192H294N54O53
Absent amino acids: CFMVW Common amino acids: APY
pI: 9.86 Basic residues: 7
Polar residues: 10 Hydrophobic residues: 10
Hydrophobicity: -95.28 Boman Index: -8544
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 68.06
Instability Index: 8368.06 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  9629200
  • Title:  Cloning of neuropeptide Y, peptide YY, and peptide Y from sea bass (Dicentrarchus labrax), a marine teleost.