HORDB

ID: hor005710
Uniprot ID: Q6RUW3
Protein name: Neuropeptide Y
Gene name: NPY
Organism: Bos taurus (Bovine)
Family: NPY family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior; GO:0008343 adult feeding behavior; GO:0032100 positive regulation of appetite
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0031410 cytoplasmic vesicle; GO:0098992 neuronal dense core vesicle

Sequence: YPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRY
Length: 36(29-64)
Propeptide: MLGSKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDLARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTGNIPRTRLEDPSMW
Signal peptide: MLGSKRLGLSGLTLALSLLVCLGALAEA
Modification: T36 Tyrosine amide
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: YES
Target: NPY1R
Target Unid: Q1RMU8
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005710_AF2.pdb

hor005710_ESM.pdb

Mass:	487915	Formula:	C190H286N54O58
Absent amino acids:	CFMVW	Common amino acids:	Y
pI:	7.52	Basic residues:	6
Polar residues:	11	Hydrophobic residues:	9
Hydrophobicity:	-114.17	Boman Index:	-10578
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	65.28
Instability Index:	6031.11	Extinction Coefficient cystines:	7450
Absorbance 280nm:	212.86