General Information

  • ID:  hor005684
  • Uniprot ID:  P06303
  • Protein name:  Pancreatic hormone
  • Gene name:  Ppy
  • Organism:  Rattus norvegicus (Rat)
  • Family:  NPY family
  • Source:  Animal
  • Expression:  pancreatic islets of Langerhans
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior; GO:0008150 biological_process
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005737 cytoplasm

Sequence Information

  • Sequence:  APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY
  • Length:  36(30-65)
  • Propeptide:  MAVAYYCLSLFLLSTWVALLLQPLQGAWGAPLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRYGKRDEDTAGLPGRQLPPCTSLLVGLMPCAAARS
  • Signal peptide:  MAVAYYCLSLFLLSTWVALLLQPLQGAWG
  • Modification:  T36 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  acts as a regulator of pancreatic and gastrointestinal functions
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P06303-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005684_AF2.pdbhor005684_ESM.pdb

Physical Information

Mass: 502436 Formula: C195H297N57O58S
Absent amino acids: CFKSVW Common amino acids: RY
pI: 8.93 Basic residues: 6
Polar residues: 11 Hydrophobic residues: 7
Hydrophobicity: -129.44 Boman Index: -11425
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 51.67
Instability Index: 5194.72 Extinction Coefficient cystines: 7450
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  NA
  • Title:  NA