HORDB

ID: hor005676
Uniprot ID: P33689
Protein name: C-flanking peptide of NPY
Gene name: npy
Organism: Xenopus laevis (African clawed frog)
Family: NPY family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region; GO:0031410 cytoplasmic vesicle; GO:0098992 neuronal dense core vesicle

Sequence: SSPETMLSDVWWRENTENIPRSRFEDPPMW
Length: 30(68-97)
Propeptide: MQGNMRLWMSVLTLCLSMLICLGTFAEAYPSKPDNPGEDAPAEDMAKYYSALRHYINLITRQRYGKRSSPETMLSDVWWRENTENIPRSRFEDPPMW
Signal peptide: MQGNMRLWMSVLTLCLSMLICLGTFAEA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005676_AF2.pdb

hor005676_ESM.pdb

Mass:	421147	Formula:	C163H238N44O51S2
Absent amino acids:	ACGHKQY	Common amino acids:	EPS
pI:	4.1	Basic residues:	3
Polar residues:	8	Hydrophobic residues:	7
Hydrophobicity:	-120.33	Boman Index:	-9291
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	35.67
Instability Index:	8268.33	Extinction Coefficient cystines:	16500
Absorbance 280nm:	568.97