HORDB

ID: hor005663
Uniprot ID: P28672
Protein name: C-flanking peptide of NPY
Gene name: npy
Organism: Carassius auratus (Goldfish)
Family: NPY family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Carassius (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SSADTLISDLLIGETESHPQTRYEDQLVW
Length: 29(68-96)
Propeptide: MHPNMKMWTGWAACAFLLFVCLGTLTEGYPTKPDNPGEGAPAEELAKYYSALRHYINLITRQRYGKRSSADTLISDLLIGETESHPQTRYEDQLVW
Signal peptide: MHPNMKMWTGWAACAFLLFVCLGTLTEG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005663_AF2.pdb

hor005663_ESM.pdb

Mass:	380419	Formula:	C144H223N37O52
Absent amino acids:	CFKMN	Common amino acids:	LS
pI:	3.81	Basic residues:	2
Polar residues:	9	Hydrophobic residues:	9
Hydrophobicity:	-51.72	Boman Index:	-6006
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	94.14
Instability Index:	2595.86	Extinction Coefficient cystines:	6990
Absorbance 280nm:	249.64