HORDB

ID: hor005659
Uniprot ID: P70074
Protein name: Gonadoliberin-1
Gene name: gnrh1
Organism: Pagrus major (Red sea bream) (Chrysophrys major)
Family: GnRH family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Pagrus (genus), Sparidae (family), Spariformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSYGLSPG
Length: 10(24-33)
Propeptide: MAPQTSNLWLLLVVMMVMSQGCCQHWSYGLSPGGKRDLDSLSDTLGDIIERFPHADSPCSVLGCAEEPPFPKMYRMKGFIGSGTDRDNGHRTYKK
Signal peptide: MAPQTSNLWLLLVVMMVMSQGCC
Modification: T1 Pyrrolidone carboxylic acid;T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005659_AF2.pdb

hor005659_ESM.pdb

Mass:	129192	Formula:	C52H70N14O15
Absent amino acids:	ACDEFIKMNRTV	Common amino acids:	GS
pI:	7.54	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	-91	Boman Index:	-801
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	39
Instability Index:	4157	Extinction Coefficient cystines:	6990
Absorbance 280nm:	776.67