HORDB

ID: hor005610
Uniprot ID: P49125
Protein name: Alpha-latrotoxin-associated low molecular weight protein
Gene name: NA
Organism: Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)
Family: arthropod CHH/MIH/GIH/VIH hormone family
Source: animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Latrodectus (genus), Theridiidae (family), Araneoidea (superfamily), Orbiculariae, Entelegynae, Araneomorphae (suborder), Araneae (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: ISPADIGCTDISQADFDEKNNNCIKCGEDGFGEEMVNRCRDKCFTDNFYQSCVDLLNKVYEEKDTPPVQE
Length: 70
Propeptide: MSKLFFVVFLCLIISVFAISPADIGCTDISQADFDEKNNNCIKCGEDGFGEEMVNRCRDKCFTDNFYQSCVDLLNKVYEEKDTPPVQE
Signal peptide: MSKLFFVVFLCLIISVFA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana
Mechanism: Co-purifies with alpha-latrotoxin-Lt1a.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005610_AF2.pdb

hor005610_ESM.pdb

Mass:	917767	Formula:	C335H514N90O120S7
Absent amino acids:	HW	Common amino acids:	D
pI:	3.91	Basic residues:	7
Polar residues:	24	Hydrophobic residues:	16
Hydrophobicity:	-79.14	Boman Index:	-18338
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	52.86
Instability Index:	4797.14	Extinction Coefficient cystines:	3355
Absorbance 280nm:	48.62

PubMed ID: 9792186
Title: The low molecular weight protein which co-purifies with alpha-latrotoxin is structurally related to crustacean hyperglycemic hormones.Black widow spider toxins: the present and the future.